Immune system may
cause reaction to cancer drug
WASHINGTON,
Mar 14: People who live in parts of the US
south may have pre-existing immunities that cause
a severe allergic reaction to the widely used
cancer drug Erbitux, US researchers reported.
They found that
patients who had the sometimes life-threatening
reactions had a pre-existing immunity to a sugar
compound found in the drug made by ImClone
Systems Inc.
The discovery,
reported in the New England Journal of Medicine,
might help explain why people living in certain
regions of the United States are much more likely
to have the reaction, the researchers said
yesterday.
Potential patients
should be tested before getting the drug, which
had global sales of 1.1 billion dollar in 2006
for use in treating colon, head and neck cancers,
the researchers said.
Erbitux, known
generically as cetuximab, is a monoclonal
antibody, a genetically engineered immune system
compound designed to target cancer cells.
But some patients
have a severe allergic reaction to the drug.
Dr Thomas
Platts-Mills of the University of Virginia and
colleagues looked at reports of these cases,
which suggest that as many as 22 per cent of
patients treated with Erbitux in Tennessee and
North Carolina reported some kind of reaction
including anaphylaxis, which can rapidly lead to
difficulty breathing, shock or fainting.
''It's stunning,''
Platts-Mills said in a telephone interview.
Even higher rates
were reported from parts of Arkansas, Missouri
and Virginia. But fewer than 1 per cent of
patients treated in the Northeast reported any
reactions.
CLASSIC IMMUNE
RESPONSE
Tests showed a
significant number of these patients were having
immunoglobulin E or IgE responses -- the classic
immune response that causes anaphylactic
seizures. Many had them almost instantly after
getting the drug, which suggests they had a
pre-existing immunity, Platts-Mills said.
His team tested
538 people, including 76 cancer patients who got
Erbitux in Tennessee, Arkansas and North Carolina
and healthy volunteers from Tennessee, California
and Boston.
Of the 76 cancer
patients, 25 developed hypersensitivity reactions
and 18 had IgE antibodies to the drug.
Of the noncancer
patients, antibodies against Erbitux were found
in 21 per cent of the samples from Nashville, 6
per cent of the samples from California and fewer
than 1 per cent of the samples from Boston.
''We all said why?
Why on Earth would they have them?'' Platts-Mills
said. Possible culprits included ticks,
roundworms and certain microbes.
Then Platts-Mills
went on a mountain hike. ''My feet started
itching and I took off my shoes and there were
all these baby ticks -- little ones,'' he said.
He realized these
insects, known locally as seed ticks, are found
only in the South -- the same states where
patients were reacting to Erbitux.
''We are making
extracts of ticks to test people for IgE
antibodies,'' Platts-Mills said. ''We need to
know much more about the immune response to ticks
in these people.''
''These intriguing
research findings not only are potentially
important to physicians treating certain cancer
patients, but also may have broader implications
for the use of immunotherapies for other
diseases,'' said Dr Anthony Fauci, director of
the National Institute of Allergy and Infectious
Diseases, which helped pay for the study.
(AGENCIES)
PPP-PML(N)
hammer out cabinet deal
ISLAMABAD,
Mar 14: The Pakistan People's Party and the
Pakistan Muslim League-N have agreed to share
berths in the cabinet of ministers and
parliamentary committees according to the
proportion of their seats in the National
Assembly.
Dawn newspaper
quoted PML-N leader Makhdoom Javed Hashmi as
saying, after a meeting of his party, the formula
for distribution of ministries at the centre and
in Punjab had been finalised. PML chief and
former prime minister Nawaz Sharif presided over
the meeting.
According to the
formula, the PPP would have 54 per cent share in
the federal cabinet, the PML-N 40 per cent and
the Awami National Party six per cent.
Mr Hashmi said the
ministries would be allocated after negotiations.
He said the heads of the parliamentary committees
would also be nominated through mutual
understanding under the same formula.
He said opposition
members would also be asked to head some
parliamentary committees.
Mr Hashmi alleged
that the presidency had made as many as 21
attempts to create rift among political parties.
It was also creating hurdles in the formation of
governments in Punjab and Balochistan.
He said the
political parties had foiled all attacks from the
Aiwan-i-Sadr or President House with the support
of the people.
The PML-N leader
said there had been no change in Nawaz Sharif's
stand on President Pervez Musharraf, whom his
party considers an ''illegal and
unconstitutional'', President.
He said lawyers,
the media and members of the civil society would
be taken into confidence about every decision.
The supremacy of
the Constitution and the restoration of judges
would be the first priority of the government.
PML-N Information
Secretary Ahsan Iqbal said Mr Sharif had taken
the party into confidence about his talks with
PPP co-chairman Asif Zardari.
He said the PML-N
had recognised the PPP's right to nominate a
candidate for the prime minister's post, but it
had requested that the person should have an
ability to implement the Charter of Democracy in
letter and spirit. He said the PML-N would fully
support the PPP's prime minister.
Mr Hashmi said
there could be a confrontation between the new
assembly and the Aiwan-i-Sadr if President
Musharraf did not respect the will of the people.
He said the people wanted the judges, who were
sacked with imposition of emergency in the
country on November 3, restored because they had
been removed unconstitutionally.
Mr Sharif has
convened the first meeting of the party's
parliamentary group at the Parliament House
before the National Assembly session on March 17.
(UNI)
EU aims to set
the pace in fighting climate change
BRUSSELS,
Mar 14: EU leaders agreed on a timetable for
action to tackle climate change that they hope
will enable them to set the pace in global talks
next year, but some voiced unease about the
methods.
The European Union
sees itself as a world leader in the fight
against global warming after EU countries agreed
last year to cut emissions by 2020 and increase
the share of wind, solar, hydro and wave power in
electricity output by the same date.
After chairing the
first day of a two-day summit, Slovenian Prime
Minister Janez Jansa told a news conference all
27 leaders agreed to adopt a liberalisation of
the European energy market in June and a package
of measures to fight global warming and promote
green energy in December.
''We must reach
agreement in the first months of 2009 at the
latest,'' said Jansa.
French President
Nicolas Sarkozy said he was hopeful of reaching a
package deal on climate change under France's
presidency of the EU in the second half of this
year.
But several
leaders said a deal would be difficult because of
conflicting national priorities.
German Chancellor
Angela Merkel led a group of countries demanding
early guarantees of special treatment for
energy-intensive industries such as steel,
cement, paper and aluminium, so they could plan
investments, diplomats said.
Britain, Sweden
and the Netherlands opposed Merkel's demand that
the EU agree in 2009 on conditions for big energy
users, saying it would weaken the EU's hand in
global negotiations on curbing emissions.
''Everybody stated
their priorities. Many were quite nervous about
liberalisation and carbon leakage,'' a senior EU
diplomat said. ''Carbon leakage'' occurs when
production is transferred to countries with lower
environmental standards.
Sarkozy told
reporters: ''The main concern is implementing a
mechanism that will hit imports from those
countries that don't play the game.''
But Merkel
believed any EU measure would have to be
compatible with World Trade Organisation rules,
diplomats said.
CURRENCY WORRIES
Failure to agree
on the details by this time next year would delay
EU laws and weaken the bloc in United Nations
talks on curbing emissions with other countries,
including the United States, in Copenhagen in
November 2009.
Leaders also
approved a watered-down Franco-German plan for a
Union for the Mediterranean to boost ties with
the EU's southern neighbours after months of
bitter wrangling.
Highlighting
threats to European economic growth, the euro hit
another record high of $1.56 on Thursday and oil
prices hovered near a peak of $110 a barrel.
That prompted the
head of the main EU employers' group,
Ernest-Antoine Seilliere of BusinessEurope, to
call for international talks on stabilising
foreign exchange markets.
But Jean-Claude
Juncker, the Luxembourg prime minister who chairs
the group of 15 euro zone countries, said he
thought growth in the area was not at risk.
Showing his green
credentials, British Prime Minister Gordon Brown
told reporters on a train to Brussels he would
propose EU sales tax breaks on eco-friendly
fridges, light bulbs and other domestic
appliances.
But European
Commission President Jose Manuel Barroso brushed
the idea aside, saying several EU states had said
they opposed it and that tax proposals required
unanimous agreement.
Aside from cutting
emissions by at least one-fifth by 2020 from 1990
levels, EU states have agreed to use 20 percent
of renewable energy sources in power production
and 10 percent of biofuels from crops in
transport by the same date.
Jansa acknowledged
growing debate among scientists and economists
about the desirability of the biofuels target,
saying: ''We're not excluding the possibility
that we'll have to amend or revise our goals.''
Environmental
pressure group Greenpeace called the emissions
target ''way short of the mark''.
''We have wasted a
lot of precious time, too much time, during
Bush's administration,'' Greenpeace's Mahi
Sideridou told Reuters, adding she expected that
whoever succeeds President George W. Bush's next
year will be more committed to action.
Some fear the cost
of tackling global warming could drive industry
out of Europe. John Monks, general secretary of
the European Union Trade Union Confederation,
called for a ''carbon tax'' on imports from less
environmentally conscious parts of the world.
(AGENCIES)
)
Cult of
celebrity 'harming children'
LONDON,
Mar 14: Celluloid heroes like Abhiskek
Bachchan or cricketers MS Dhoni and Sachin
Tendulkar are often idolised by kids. But, a new
study has claimed that obsession with celebrities
is actually harming the children.
Researchers in
Britain have carried out the study and found that
the cult of celebrity is producing a generation
that believes education and hard work are not at
all important in achieving success.
According to the
study by the Association of Teachers and
Lecturers in the United Kingdom, these children
would grow up to feel a sense of failure,
alienation and low self-esteem when celebrity
status is not achieved.
"Celebrities
can have a positive effect on pupils. They can
raise pupils' aspirations. But we are concerned
that many pupils believe celebrity status is
available to everyone.
"They do not
understand the hard work it takes to achieve such
status and do not think it is important to be
actively engaged in school work as education is
not needed for a celebrity status," the
association's General Secretary Mary Bousted was
quoted by 'The Daily Telegraph' as saying.
The researchers
came to the conclusion after they conducted a
survey in which 70 per cent of teachers in
primary and secondary schools said that the cult
of celebrity was perverting children's
aspirations and expectations.
About 37 per cent
of the teachers interviewed believe their pupils
want to be famous for being famous. They fear
that many youngsters do not realise how hard
their idols have worked to earn their fame.
According to 53
per cent of the teachers surveyed, David and
Victoria Beckham are the celebrities most British
students model themselves on.
Overall, sports
stars are the most popular type of celebrity with
pop singers, such as the Sugababes and Leona
Lewis, ranking a close second, 60 per cent of
teachers said in the survey. (PTI)
Drowning,
suffocation among leading
causes of child
death: UN
NEW
YORK, Mar 14: Injuries resulting from drowning,
suffocation and road accidents are among the
leading killers of Asian children, a new study
shows.
The study,
conducted jointly by the United Nations
Children's Fund (UNICEF) and Alliance for Safe
Children (ASC), found that risk of death from
injuries rises after infancy as children become
independent and danger from infectious and
non-communicable diseases decreases.
"If we are
ultimately going to meet the Millennium
Development Goal (MDG) to reduce child mortality,
it is imperative that we take action to address
the causes of childhood injury," said
Anupama Rao Singh, Regional Director of UNICEF
East Asia and Pacific, calling for increased
investment in public awareness campaigns and
arming children and their parents with knowledge
and skills.
Working in
partnership with local public health teams,
in-person interviews for the study were done in
over half a million households, comprising more
than 2 million people in five countries:
Bangladesh, China, the Philippines, Thailand and
Vietnam.
The causes of
death and disability among a representative
sample of all children up to 18 years of age were
reliably recorded for the first time ever in
these nations, UNICEF said.
The study found
that the causes of injuries differ by age group.
Infants under 12 months are not as exposed to
injury, while toddlers between one and four years
of age are at the greatest risk of drowning.
(PTI)
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