Blood thinners like
aspirin may fight cancer-study
WASHINGTON,
Mar 8: Blood-thinning drugs such as aspirin
may help fight cancer by denying shelter to
wandering tumor cells, US researchers reported.
Experiments in
mice showed that combining aspirin with an
experimental anti-clotting drug slowed the growth
and spread of breast and melanoma tumors.
Blood cells called
platelets shelter and feed tumor cells in the
bloodstream, making it easier for cancer to
spread, or metastasize, the team at Washington
University in St Louis said.
Writing in the
Journal of Cellular Biochemistry, they said
inactivating platelets may help slow or prevent
this spread.
The study could
help support other findings that show people who
take aspirin or similar drugs that affect a gene
and protein called COX-2, including aspirin,
ibuprofen and the COX-2 inhibitor Celebrex, have
a lower risk of some cancers.
There is also some
suggestion that taking aspirin or ibuprofen along
with chemotherapy may make the chemo more
effective.
''Past research
has shown that tumor cells activate platelets and
that mice with defective platelets have
significantly fewer metastases,'' Dr Katherine
Weilbaecher, who helped lead the study, said in a
statement yesterday.
''We also know
that platelets have several traits that can aid
tumor cells, and we are working to break up that
potentially lethal partnership.''
The researchers
used ordinary aspirin combined with an
experimental antiplatelet drug called APT102.
Made by St. Louis-based APT Therapeutics, the
drug interferes with clotting.
When they injected
mice with breast cancer and melanoma cells, the
tumors quickly spread to the bone.
But when the mice
got aspirin and APT102, the tumors that grew and
spread were much smaller. Neither drug had an
effect on its own, perhaps because
platelet-making processes must be attacked from
several angles, Weilbaecher said.
''Aspirin prevents
platelets from making thromboxane, a substance
that facilitates clotting,'' Weilbaecher said.
''APT102 is an
especially interesting drug because it gets rid
of a compound called ADP, which tumor cells
release and which stimulates platelets to clump.
So APT102 prevents platelet activation in
response to tumor cells.''
The company
provided the drug but did not pay for the study.
''Anti-platelet
drugs such as (aspirin) plus APT102 could be
valuable experimental tools for studying the role
of platelet activation in metastasis as well as a
therapeutic option for the prevention of bone
metastases,'' the researchers wrote.
Weilbaecher and
colleagues are testing their theory in women with
advanced breast cancer to test aspirin and the
anti-clotting drug Plavix, another antiplatelet
drug, to see if the combination reduces the
number of tumor cells in the blood.
Plavix, one of the
world's best-selling drugs, is sold by
Bristol-Myers Squibb Co and Sanofi-Aventis.
(AGENCIES)
Kerela man
plunges to death from a building in Bahrain
DUBAI,
Mar 8: A 50-year-old man hailing from
Kerala plunged to his death while painting a
building in Bahrain.
Parpupara Nanu,
50, was standing on a scaffolding painting a
building when he fell to the ground on Thursday
at the site of the USD 6 billion Durrat Al-
Bahrain project.
"One hour
before his death he complained of heart pain and
requested some rest for a little time.
Afterwards, he went back to work and fell
unconscious," a colleague was quoted as
saying by media.
Nanu apparently
suffered a heart attack, he said.
Hailing from
Kozhikode, Nanu had lived in Bahrain for 13 years
and is survived by his wife and a six-year-old
daughter. (PTI)
Astronomers
capture rare video of meteor
falling to Earth
NEW YORK, Mar 8: Astronomers claim to have
captured a rare video of a meteor falling to
Earth.
Using a network of
all-sky cameras in Southern Ontario, the
astronomers at the University of Western Ontario
in Canada have shot the large fireball on
Wednesday.
According to Wayne
Edwards, one of the researchers, "Most
meteoroids burn up by the time they hit an
altitude of 60 or 70 kilometres from Earth.
"We tracked
this one to an altitude of about 24 kilometres so
we are pretty sure there are at least one, and
possibly many meteorites, that made it to the
ground."
The team hopes to
enlist the help of local residents in recovering
one or more possible meteorites that may have
crashed in the Parry Sound area of Ontario.
According to
Edwards, the lab can narrow the ground location
where the meteorite would have fallen, to about
12 square kilometres and have created a map that
may assist in locating the meteorite.
The rock, or
rocks, would probably weigh a kilogramme or
slightly more.
"We would
love to find a recovered meteorite on this one,
because we have the video and we have the data
and by putting that together with the meteorite,
there is a lot to be learned," Edwards was
quoted by the ScienceDaily as saying.
(PTI)
Mexico soldiers
catch corrupt police red-handed
MEXICO
CITY, Mar 8: Mexican soldiers caught six local
police chiefs red-handed at a gas station
sporting luxury watches and carrying envelopes
stuffed with wads of cash, the army said.
Soldiers in the
northern state of Tamaulipas rushed to the gas
station yesterday after a tip-off that members of
the powerful Gulf drug Cartel were there. They
detained six men who turned out to be municipal
police commanders for suspicious activity, the
army said.
Searches of the
men produced six envelopes filled with thousands
of dollars each as well as Rolex and Cartier
watches, priced far beyond the means of
policemen's salaries, the army said.
The police bosses,
from various local forces in Tamaulipas, said the
cash was either wages, expense payments or their
own savings. The soldiers turned them over to
federal investigators.
Mexican police,
especially in northern states riddled with drug
traffickers, are widely seen as corrupt and prone
to top up their meager wages with cash bribes
from drug gangs that smuggle cocaine across the
border to the United States.
Tens of thousands
of troops sent by President Felipe Calderon to
crack down on the cartels have disarmed entire
police forces in the border city of Tijuana and
other towns on suspicion officers were in the pay
of drug gangs. (AGENCIES)
Non-stimulant
curbs ADHD in fragile X syndrome
NEW
YORK, Mar 8: L-acetylcarnitine (LAC), a natural
substance devoid of side effects, may be
considered an alternative to stimulants to
control attention deficit hyperactivity disorder
(ADHD) in children with the genetic disorder
known as fragile X syndrome, researchers conclude
based on study they conducted.
Fragile X syndrome
is an inherited form of mental retardation. The
condition, which may also cause autism and ADHD,
results from a genetic defect on the X
chromosome.
ADHD is common in
young boys with fragile X syndrome and
alternatives to methylphenidate and other
stimulant medications are needed, note Dr.
Giovanni Neri from Universita Cattolica in Rome
and colleagues in a Rapid Publication of their
study posted online by the American Journal of
Medical Genetics.
In a previous
study, the team showed that LAC treatment
significantly reduced hyperactive behavior in
fragile X syndrome boys.
With the current
study, the investigators sought to determine the
effectiveness of LAC in a larger sample of boys
with fragile X syndrome and an established
diagnosis of ADHD.
The 63 boys who
participated in the study were between 6 and 13
years old. Seven dropped out while 56 completed
one year of treatment, and 51 were included in
the final analysis. Of these, 24 received LAC and
27 received placebo.
''We observed a
stronger reduction of hyperactivity and
improvement of social behavior in patients
treated with LAC, compared with the placebo
group,'' Neri told Reuters Health.
''LAC is a natural
substance, playing an important role in the
energy metabolism of the cells, and it is devoid
of adverse side effects,'' the researcher
emphasised. ''Therefore, in our view, it
represents a safe alternative to the use of
stimulant drugs for the treatment of ADHD in
fragile X syndrome children.''
These findings
might, in the future, be extended to ADHD in
non-fragile X children, who represent a much
larger group of individuals, Neri added.
(AGENCIES)
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