Scientists pinpoint
why some people become addicts
LONDON,
Feb 26: Scientists have identified the part
of the brain that may hold the key to why some
cocaine users become addicts while others just
take the drug socially, researchers said today.
Brain scans of
cocaine users while they performed simple
computer tasks showed changes in the part of the
brain responsible for controlling behaviour and
making appropriate decisions, they said.
This could explain
why some people find it easier to quit than
others and may shed light on long-term addiction,
said Hugh Garavan, a cognitive neuroscientist at
Trinity College Dublin who presented his research
to a meeting of the Royal Society in London.
''Most people who
try to quit drugs relapse,'' Garavan said in a
telephone interview. ''It might have to do with
how intact these brain regions are.''
Cocaine, initially
used in patent medicines, beverages and tonics
around the turn of the 20th Century, is a drug
that in powdered form can be snorted or dissolved
in water and injected. Its derivative crack
cocaine is even more powerful.
An estimated 1 to
3 percent of adults in developed countries use
the drug, which has been linked to a number of
medical, psychological and social problems
including crime, violence and the spread of
diseases like AIDS and hepatitis, according to
the World Health Organisation.
Garavan and
colleagues used MRI scans to show that cocaine
users had reduced neural activity marked by
reduced blood flow to the part of the brain
involved in things like problem solving, decision
making and controlling behaviour. Some people
were administered cocaine in the experiments.
''This research
helps us move away from thinking of drug
dependence as a moral weakness and allows us to
see it as more of a medical condition.''
It was unclear
whether the changes were due to the drug itself
or whether some kind of natural mechanism in the
brain triggers the change, Garavan said.
But better
understanding the brain's response to cocaine
could eventually help predict people most at risk
of developing an addiction and lead to better
treatments, he added.
''One would hope
this research would guide the development of new
treatments including the development of
pharmacological solutions to addiction,'' Garavan
said.
(AGENCIES)
Political crisis
in Kenya should be resolve immediately: UN
UNITED
NATIONS, Feb 26: United Nations has said that the
political crisis created after the elections in
Kenya should be immediately resolved to stop
further escalation of violence in that country.
If there is no
quick resolution to the political crisis, the
risk of a fresh surge in violence, more
displacement and further polarization of society
will be very high, John Holmes UN Emergency
Relief Coordinator and Under-Secretary-General
for Humanitarian Affairs said.
"The
humanitarian consequences of this could dwarf
anything we have seen so far," he said,
noting that some 1,000 people have already lost
their lives and more than 300,000 driven from
their homes since elections in which President
Mwai Kibaki was declared the winner over
opposition leader Raila Od inga.
Holmes while
briefing the Security Council on his visit to the
East African country from February 8 to 11, said
he made it clear to the Kenyan parties that the
full weight of the UN is behind the mediation
process, led by former Secretary-General Kofi
Annan, that was attempting to reconcile the
differences over the election results.
To avoid future
violent explosions, however, it is also crucial
to address decades-long grievances over land,
poverty and wide economic inequalities in a
context of strong population growth and limited
availability of land, he said.
In addition, he
added, political manipulation of land and tribal
issues would have to be prevented through
constitutional and electoral reform, and that
there must be accountability for those
responsible for the current violence, human
rights abuses and failures to protect civilians.
(PTI)
Exercise may cut
gallstone risk.
NEW
YORK, Feb 26: Exercise is good for mice and
humans, but appears to be bad for gallstones,
according to the findings of a study conducted
with mice.
Dr Kenneth R
Wilund and colleagues found that the overall
gallstone weight was 2.5-fold greater in
sedentary mice compared with mice that exercised.
The researchers suggest that exercise may provide
similar benefit to humans.
''The basic
physiology of gallstone formation is pretty
similar in humans and mice,'' Wilund said. Many
of the proteins involved in the liver's
cholesterol and bile acid metabolism are very
similar, he said.
''So it is
reasonable to suggest that the changes we believe
were responsible for the reduction in gallstone
formation in the exercise-trained mice could also
occur in response to exercise training in
humans,'' commented Wilund, of the University of
Illinois, Urbana.
He and his
colleagues fed 50 gallstone-susceptible mice
standard chow that was supplemented to increase
gallstone formation. They placed half the mice on
a 12-week endurance exercise regimen that
involved 45 minutes of running, five days a week.
The remaining mice were sedentary for 12 weeks,
the investigators report in the Journal of
Applied Physiology.
At the end of the
study period, the animals were euthanized and the
gallstones were removed. The total weight of the
gallstones from the sedentary mice was 143
milligrams compared with 57 milligrams for
exercising mice, the investigators note.
''In most
situations, gallstone formation in humans occurs
over a very long period of time -- probably
years,'' Wilund said. ''As a result, it would be
difficult to do a similar study in humans.''
However, the
process of gallstone formation is similar enough
between mice and humans to infer that exercise
may also limit gallstone formation in humans, he
and colleagues note.
''It is well
established that chronic exercise reduces the
incidence of chronic diseases such as heart
disease, diabetes, and certain types of cancer,''
Wilund continued. ''This study provides
preliminary evidence that perhaps we can add
gallbladder disease to this list.''
(AGENCIES)
Scientists
discover new way to store information via DNA
NEW
YORK, Feb 26: Researchers at the University of
California claim to have discovered a new system
to encode digital information within DNA.
According to the
researchers, this method relies on length of the
fragments obtained by the partial restriction
digest rather than the actual content of
nucleotide sequence, the 'Langmuir' medical
journal has reported.
"What we
developed is a method to encode a message in DNA
in a way that does not require an expensive
sequencing machine. The decoding still requires a
wet lab procedure, but the experimental procedure
is significantly easier," said lead
researcher Prof Stefano Lonardi.
But, why is this
discovery important? Well, the human genome
consists of the equivalent of approximately 750
MB of data -- a significant amount of storage
space.
However, only
about three per cent of DNA goes into composing
the more than 22,000 genes that make us what we
are. The remaining 97 per cent leaves room to
encode information in a genome, allowing the
information to be preserved as well as replicated
in perpetuity.
Given the size of
the DNA fragments, one could store a large amount
of information in a very small space. By storing
messages within DNA, organisations can
"tag" objects to verify authenticity,
as well as to inconspicuously send data to a
specific destination, according to the
researchers.
"Already
there are several companies using DNA to tag
objects that they certify to be original and
which then can be very difficult to
counterfeit," Prof Lonardi wrote in the
American Medical Society's journal. (PTI)
Indian herb may
help diabetics control blood sugar
NEW
YORK, Feb 26: An extract of Coccinia indica, a
perennial herb that grows abundantly in India,
may help people with mild type 2 diabetes control
their blood sugar levels, the results of a new
study suggest.
In the journal
Diabetes Care, researchers note that while
Coccinia indica, also known as Coccinia
cordifolia, has been widely used in traditional
treatments of diabetes, carefully controlled
studies have not been done.
To examine the
effects of this herb on blood sugar levels, the
India-based researchers randomly assigned 60
adults with newly detected type 2 diabetes to
receive Coccinia extract or placebo. The subjects
were between 35 and 60 years old and were being
treated with diet and lifestyle modification
only.
According to Dr
Rebecca Kuriyan, from the Institute of Population
Health and Clinical Research in Bangalore, and
colleagues, there were significant differences in
blood sugar favoring Coccinia extract over
placebo after 90 days of treatment.
Fasting blood
sugar levels at 90 days in people taking the
Coccinia extract fell by an impressive 16
percent, while fasting blood sugar levels rose
slightly in the placebo takers. Likewise,
patients in the Coccinia extract group had an
18-per cent decrease in post-meal blood sugar
levels at the study's end, whereas the placebo
group experienced a small increase in post-meal
blood sugar levels.
This study
suggests that Coccinia extract has a potential
blood sugar lowering action in patients with mild
diabetes. Kuriyan and colleagues note however
that additional studies are needed to identify
the mechanisms involved.
(AGENCIES)
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