Scientists
propose sharing genetic data on birdflu
GENEVA, Aug 25: Leading scientists called
yesterday for the establishment of a global
consortium to share genetic data from bird flu
cases, deemed vital for tracking mutations and
developing a vaccine against a human pandemic.
In a
letter to science journal Nature, 70 scientists
and health officials said the current level of
collecting and sharing of data on the H5N1 avian
influenza virus was ''inadequate ... Given the
magnitude of the threat''.
In
its press release, Nature (www.Nature.Com/nature)
went further accusing some scientists and
organisations of ''hoarding'' sequence data,
often for years, so as to be the first to publish
it in academic journals.
''We
propose to expand and complement existing efforts
with the creation of a global consortium -- the
Global Initiative on Sharing Avian Influenza Data
(GISAID) -- that would foster international
sharing of avian influenza isolates and data,''
wrote the scientists, who include six Nobel
laureates.
Researchers
taking part in the consortium would agree to
share their sequence data, analyse the findings
jointly and publish the results collaboratively,
they said.
Bird
flu remains essentially an animal disease, but
experts fear that the H5N1 virus could mutate
into a form that could pass easily among humans
and kill millions.
The
virus has killed 141 people since 2003 among 241
known cases in 10 countries, mostly in Asia, the
World Health Organisation (WHO) says.
THOSE
NOT SHARING
Currently
countries send samples taken from suspect cases
for confirmation to international laboratories
recognised by the WHO, but they must give the
greenlight for the United Nations health agency
to release the genetic data.
China,
Thailand and Vietnam, three of the most hard hit
by the virus, were among those not sharing
genetic information, although Indonesia has
recently agreed to do so, the New York Times
reported yesterday.
The
WHO, which declined to confirm or deny the
newspaper report, yesterday renewed its appeal
for putting all genetic sequencing information in
the public domain in a statement issued on its
website (www.Who.Int) to coincide with the
letter.
''WHO
believes that timely sharing of H5 virus sequence
information is a critical step for improving the
international response to the avian and pandemic
influenza threat,'' it said.
Genetic
data is important for vaccine development,
preparing reagents used for diagnostic purposes
and monitoring drug-resistant strains, according
to the Geneva-based agency.
Under
the proposed consortium, data would be deposited
in three public data bases in Japan, Europe and
the United States.
Scientists
must have full access to comprehensive genetic
sequencing, as well as clinical and
epidemiological data from both animal and human
virus isolates, the scientists said.
WHO
spokesman Dick Thompson said the agency
''absolutely supported'' the idea. ''Rapid
sharing of sequence information is important but
it has to be linked with epidemiological and
clinical data to be complete,'' he
added.(AGENCIES)
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Music sales slump
"to be eased by online boom"
LONDON,
Aug 25: The explosion in online music sales
is set to continue and will start to halt the
decline in overall sales of recorded music in
Europe, but not until 2010, according to a report
yesterday.
Within four years,
European spending on online music will rise to
more than 1.1 billion euros (746 million pounds)
from just 121 million euros in 2005, media
researchers Screen Digest said.
''Online music has
been booming. However, online sales alone are not
going to be enough to halt the decline in music
sales,'' said Screen Digest's Dan Cryan.
''The music
industry needs to make the most of new delivery
platforms. We believe that with the right
strategy -- including mobile and online -- the
worst might be over by 2010,'' the author of
''Online Music in Europe: Market Assessment and
Forecast'' said in a statement.
The overall
European music market has lost 22 per cent of its
value since 2001 due to a combination of factors,
including piracy and the shift by retailers
towards DVDs, books and mobile phones at the
expense of CDs.
Screen Digest said
it was likely the growth in DVD sales was partly
responsible for the drop in physical music sales.
But, while illegal
downloads continue to be a problem, the situation
is improving.
Data from the
music industry body, the International Federation
of the Phonograhic Industry (IFPI), indicate
online piracy is declining -- the number of
tracks available on illegal file sharing networks
fell to 885 million last year from 1.1 billion in
2003.
A survey by market
research group Forrester in March forecast that
online music sales will grow rapidly over the
next five years, although traditional music sales
will still make up almost two thirds of revenues
in 2011.(AGENCIES)
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Prosecutors
for review of document release in Sears
case
MIAMI, Aug 25: Federal prosecutors
asked a judge to review how the media
obtained confidential information in the
case of seven men accused of plotting
attacks against Chicago's Sears Tower and
government buildings.
Prosecutors
want a judge to find out whether an order
sealing documents in the case was
violated.
The
request came Thursday after a Miami
television station obtained and on
Tuesday aired video that prosecutors said
was not public. The WFOR-CBS4 report
included government surveillance video
and photographs and video of the Federal
Justice Building taken by the men,
prosecutors said in a court filing.
Prosecutors
had said the men shot footage of
buildings that were to be targeted.
Copies of the video reports were also
posted on the station's Web site. Video
reports were also aired on Wednesday and
Thursday.
Shannon
High-Bassalik, the station's vice
president for news, said through a
representative that it is not the
station's policy to comment on pending
legal matters.
An
attorney for the group's alleged
ringleader also tried to get the station
to stop airing the footage, but a judge
denied the request Wednesday.
Media have
obtained confidential materials connected
to the case in the past. US District
Judge Joan Lenard previously warned
attorneys not to release nonpublic
documents.
Neither
the US Attorney's Office nor the FBI had
released the materials to the media, the
document said. (AP)
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Elderly
less likely to wake to smoke alarm
NEW YORK, Aug 25: The high-pitched
signal typically used in smoke alarms may
not wake older adults, according to a
study conducted by the Fire Protection
Research Foundation. In comparative tests
on various alarm sounds, adults aged 65
years and older were much more likely to
wake to a mixed-frequency signal than a
pure high-frequency signal used in
standard US smoke alarms.
Household
smoke alarms reduce the chances of dying
in a fire by up to 50 per cent when
present and working properly. However,
studies have shown that the elderly do
not fully benefit from smoke alarms,
particularly during the overnight hours
when they are asleep.
According
to the National Fire Protection
Association, older adults are more than
twice as likely to die in a home fire as
the average person.
The
current study investigated arousal from
sleep in 42 adults aged 65 to 85 years in
response to various signals including the
high-frequency signal used in most US
smoke alarms, a mixed-frequency signal,
and a male voice saying ''Danger, Fire,
Wake Up.''
The
high-pitched smoke alarm signal was least
likely to wake the study subjects,
Dorothy Bruck from Victoria University,
Australia and the study team reports. The
male voice also performed poorly.
The mixed
signal was most effective in waking
sleeping elderly.
The study
also found that the volume needed to wake
up to the high-frequency signal was
significantly higher than that needed to
wake up to the mixed-frequency signal.
''The high
frequency alarm signal currently found in
smoke alarms should be replaced by an
alternative signal that performs
ignificantly better in awakening most of
the adult population, once the nature of
the best signal has been determined,''
the authors recommend.
In the
meantime, they encourage the use of
interconnected smoke alarms that include
an alarm in each bedroom to increase the
chance of sleeping individuals being
woken by an alarm.
The study
also tested the performance abilities of
older adults upon awakening suddenly to a
smoke alarm. The results suggest a
decrease in physical functioning of
around 10 per cent to 17 per cent may be
expected during the first five minutes
after waking up. There were, however,
''no important'' effects on simple or
complex cognitive functioning.(AGENCIES)
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Deaths
from anorexia declining in Sweden
NEW YORK, Aug 25: The mortality among
adolescent women with the eating disorder
anorexia nervosa has waned -- at least in
Sweden -- based on a comparison of
records for two time periods,
investigators report. They think that
improved detection and better treatment
may be the primary reasons for the
improved outcomes.
Dr Frank
Lindblad of the Karolinska Institute in
Stockholm and colleagues analyzed data
from two cohorts of women. Their first
cohort included 564 female patients born
between 1958 and 1967 (mean age 16.4
years) first hospitalized for an eating
disorder between 1977 and 1981, with
follow-up until 1992.
The second
cohort was comprised of 554 females born
between 1968 and 1977, hospitalized for
the first time for anorexia nervosa
between 1987 and 1991, at an average age
of 15.9 years, and who were followed
until 2002.
Nineteen
of the 25 deaths (3.4 per cent) that
occurred in first patient cohort were
probably associated with anorexia
nervosa, the authors report.
In the
second cohort, 7 deaths occurred, of
which 4 (0.72 percent) were likely
related to the eating disorder.
''Our
mortality figures seem to be lower than
what has generally been reported before
in most countries,'' Lindblad noted.
The use of
cognitive psychotherapy has become more
popular (in Sweden and other countries)
over the last 10 years, the investigator
noted, ''but it would not be justified
from our findings to say that this is an
important factor.''
Furthermore,
''Mortality rates among other mental
disorders have remained relatively
stable,'' the author added, ''which may
mean that general changes in psychiatric
care cannot account for the improvements
in survival among patients with anorexia
nervosa.''
Instead,
''We believe that the improvement is a
result of a combination of factors,'' he
continued. ''The most important factors
are probably the result of better medical
care, including treatment of nutritional
emergency states; and the establishment
of specialized units during the second
period. The latter implies that patients
have been taken care of by professionals
with more specific experience of eating
disorders.''
In
addition to the factors noted above, the
investigators also attribute better
outcomes to increased awareness of the
condition and prevention of
suicides.(AGENCIES)
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Don't
make us scapegoats, say German Muslims
BERLIN, Aug 25: German Muslims have
urged the government not to make them
scapegoats over terrorism fears, saying
that would only fan radicalism.
Authorities
said last week the main suspects in two
attempted train bombings in western
Germany may have been part of a wider
Islamic network. Two Lebanese men have
been arrested.
Germany's
Central Council of Muslims said it had
received threats of violence and urged
Germans to work together to ensure
terrorists did not succeed in breaking up
society.
''Instead
of threatening sanctions or portraying
Muslims as scapegoats, politicians must
send a signal that we are all part of the
same world and we must work together to
keep it peaceful,'' said General
Secretary Aiman Mazyek.
''Unfortunately,
I am hearing very few words to this
effect from politicians, the church and
other public bodies,'' he said.
Interior
Minister Wolfgang Schaeuble this week
urged Muslim groups to work with
authorities to tackle militancy. He
suggested police informers could
infiltrate Islamist groups.
Some
German media question whether the
relative harmony between Germans and
their immigrant communities can last.
''We will
have to get used to trusting nobody. Not
the honest foreign student, the kebab
cook or waiter with Arabic eyes,'' wrote
columnist Franz Josef Wagner in
top-selling Bild tabloid.
SEPTEMBER
11 LINK
Germany
introduced tighter controls on Islamist
groups after three of the four suspected
suicide pilots in the September 11, 2001
attacks on the United States, including
alleged plot leader Mohamed Atta, were
found to have lived in Hamburg.
However,
Germany's Nazi legacy makes a crackdown,
which some could see as an infringement
of civil liberties, problematic.
Inssan, a
group to promote Muslim integration, said
politicians should not push Muslims to
the edge of society.
''I am
worried about radicalisation. Politicians
need to do more to help,'' Inssan's
Chaban Salih told Reuters. ''Politicians
must work with us. They should go to
mosques, there should be more workshops
and discussions about how we work
together to fight this.''
Turks make
up Germany's largest Muslim group. About
1.8 million citizens with Turkish
passports live in Germany plus about
700,000 first and second generation
Germans.
In July,
German Chancellor Angela Merkel met
immigrant organisations to draft an
integration strategy and a follow-up
conference on Muslims in Germany is
planned for September. (AGENCIES)
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Anger
as 2005 Bordeaux wine fetches record
prices
PARIS, Aug 25: French lovers of
Bordeaux red wine are angry they cannot
afford to drink the acclaimed 2005
vintage which is breaking price records
before it has even been bottled.
A case of
the top end wine is on sale at more than
double the previous record even though it
will not be delivered until 2008 at the
earliest. Owners should then wait at
least another 10 years before cracking it
open.
''We
think, and everybody that has tasted it
agrees, that 2005 is an exceptional
vintage,'' said Paul Pontallier, general
director of Chateau Margaux, one of five
producers to carry the distinguished
first-growth label.
The
influential American wine critic Robert
Parker awarded Chateau Margaux 96-100 out
of a maximum of 100 after a tasting in
the spring.
Vintners
Berry Brothers and Rudd in London is
selling cases (12 bottles) of Chateau
Margaux for 5,340 pounds (9,430 dollar).
That is an increase of 540 pounds from
the end of June when the wine 'en
primeur' (still in casks) first went on
sale at the highest release price for
Chateau Margaux.
The most
expensive year before 2005 was in 2000
when the release price was 2,000 pounds a
case. A case of 2004 Chateau Margaux en
primeur went for 1,080 pounds.
TOO
EXPENSIVE?
The
chateaux, which set the initial prices
for the wine before selling it on to
their distributors, have been criticised
for being greedy.
''It's too
much for me, because what happens on
vintages like that is that it becomes a
vintage where the French consumer can no
longer buy,'' said Yannick Branchereau,
director of Lavinia France, a vintner in
Paris.
''When you
have a first class vintage that goes
beyond 500 euros before tax, when you
don't even have a bottle of wine yet,
that is very expensive.''
The market
for top end Bordeaux is dominated by
wealthy foreigners, some buying for
investment purposes.
Pontallier
and other producers defend their pricing
policies which they say take account of
market conditions, and in 2005 a drought
which led to a smaller harvest.
''We had
remarkable weather. It was very dry and
hot,'' he said. ''It was an exceptional
year, there was enormous demand and there
was a reduced supply.''
Strong
economic growth in many countries helped
to support demand and vineyards are
attracting new interest from rich
businessmen in Asia and eastern Europe.
''We have
two huge markets which are just starting
to skim the surface for drinking the top
wines -- China and Russia,'' said Simon
Staples, sales director at Berry Brothers
in London.
''We've
got people walking into our shop saying
they want to buy a cellar please, and
it's 2.3 million pounds and they just
want the best. They don't want the 20-30
euros bottle of wine. That's not what
cooks their biscuit.''
Time will
tell whether the Bordeaux 2005 will turn
out to be a good investment. If it proves
to be a classic vintage once it has been
bottled, it should continue to rise in
value.
A case of
Chateau Latour from 1982 now costs around
10,000 pounds a case and its value should
continue to rise because of its rarity.
Staples said his company just sold a case
of Chateau Latour from 1961 for 36,000
pounds.
One threat
to the 2005 prices could come from this
year's crop, which is still on the vines
and also looks promising.
If 2006
turned out to be another good one, it
might undermine the stratospheric prices
for 2005.
''The
conditions we have seen up till now, and
we're still a month away from the
harvest, have been less exceptional than
in 2005 but still correspond to a good
vintage,'' said Pontallier. (AGENCIES)
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US has new
safety rules for unmanned rocket
launches
WASHINGTON,
Aug 25: The
Columbia space shuttle accident
has prompted the Government to
come up with new safety rules for
unmanned rocket launches.
The Federal Aviation
Administration and the Air Force
Space Command were announcing the
new safety standards for
commercial rocket launches today.
They'll take effect in one year.
"It has a lot
to do with the Columbia
accident," said Patricia
Grace Smith, associate
administrator of the FAA Office
of Commercial Space
Transportation. Smith was
referring to the 2003 accident in
which the space shuttle shattered
on its return to Earth, killing
seven astronauts.
The Columbia
Accident Investigation Board
found that "building and
launching rockets is still a very
dangerous business, and will
continue to be so for the
foreseeable future while we gain
experience at it." The board
concluded that formal
requirements are essential for
public safety.
The rules cover
unmanned rockets that are
jettisoned into the atmosphere
after they use up their fuel.
They typically carry satellites
into space for communications and
scientific purposes. About 180
rockets have been launched
commercially in the US, and there
have been no injuries, Smith
said.
The concern, though,
is that a rocket could veer off
in the wrong direction and
explode over a populated area.
"It's not just
the big companies that are
launching hese rockets now,"
George Nield, deputy associate
admimistrator for commercial
space transportation said.
"Companies are talking about
launching from other
places."
With the new safety
rules, he said, "Even the
new folks know exactly what's
expected of them." (AP)
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Outlook
good after swimming-related lung problem
NEW YORK, Aug 25: A few people are
prone to develop fluid build-up in the
lungs -- that is, pulmonary edema --
after swimming, either on the surface or
while scuba diving. Now, a team of
physicians has shown that there are
apparently no long-term consequences from
the condition, once individuals recover.
According
to Dr. Richard Thomas Mahan, with the
Naval Medical Research Center in Silver
Spring, Maryland, and his associates, the
symptoms of swimming-induced pulmonary
edema are sudden onset of breathlessness
or coughing up blood during or
immediately after swimming. This occurs
in the absence of any aspiration of water
or any sign of infection.
The team
assessed the cardiopulmonary function of
11 otherwise-healthy patients who had
recovered from swimming-induced pulmonary
edema at least 1 month before. The
results were compared with those from 9
similar but unaffected ''control''
subjects. All of the study participants
were male US Navy Special Warfare
members.
According
to the investigators' report in the
Clinical Journal of Sports Medicine, the
cases and controls did not differ
significantly in their results on
pulmonary function tests and
cardiopulmonary exercise testing.
Moreover,
''there was no evidence of obstructive or
restrictive lung disease,'' the
researchers report, or of any other
underlying abnormalities that would
explain why some individuals develop
swimming-induced pulmonary edema.
Mahan and
his associates suggest that the condition
may result from the combined effects of
immersion and increased pressure in
capillaries brought on by
exercise.(AGENCIES)
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White
House says new stem cell method
'encouraging'
WASHINGTON, Aug 25: The White House has
said it was encouraged by a new method
for embryonic stem cell research, an
advance that could help resolve President
George W Bush's objections to what he
views as the destruction of life.
Bush used
his first veto last month to block
increased federal spending for such
research, despite strong public support
for the effort to combat diseases like
Alzheimer's and Parkinson's.
''The
president believes (the new research)
deserves a good look, he is encouraged
that there are scientists who are
continuing to look for innovative ways to
do stem cell research that would not
involve the destruction of embryos,''
White House spokeswoman Dana Perino said
yesterday.
But
experts said the technique announced on
Wednesday by Advanced Cell Technology
won't resolve ethical debates and
political battles that have divided the
rest of the country for years.
Conservative
religious groups, for example, said the
Massachusetts company's announcement did
not change their view the research
destroyed potential human life.
Advocates
of increased research said it was a vain
attempt to resolve a debate about medical
ethics through science.
''This
isn't a technique that's going anywhere.
This isn't an alternative to anything,''
said Arthur Caplan, director of the
University of Pennsylvania Center for
Bioethics.
Stem
cells, which can develop into any kind of
body tissue, are prized by medical
researchers who believe they can lead to
tailored treatments for diseases
including cancer and diabetes.
Though
they are available from many sources many
experts say the most powerful and
versatile cells may be those taken from
embryos. Religious conservatives oppose
this process because those embryos are
destroyed when the cells are removed.
SINGLE
CELL REMOVED FROM EMBRYO
Opinion
polls show strong support for expanding
federally backed embryonic stem cell
research and the issue could figure
prominently in November's congressional
elections.
ACT's
method, described in the science journal
Nature, takes a single cell from an
eight-celled embryo without harming it.
But that
single cell must be combined with other
cells harvested earlier, presumably from
a process that destroyed embryos, said
Michele Shoun, editor of Baptists for
Life, a publication for ministers that
opposes stem cell research involving
embryos.
''I
appreciate that someone is trying to work
with our concerns, but I don't think
they've quite reached that,'' Shoun said.
Richard
Doerflinger, a bioethics expert with the
US Conference of Catholic Bishops, said
the experiment was unethical because it
involved discarding embryos.
''The
Catholic Church is open to considering
all ethically acceptable avenues of stem
cell research. The new study ... however,
raises more ethical questions than it
answers,'' he said.
Stanford
University medical researcher Bill
Hurlbut, who sits on the President's
Council for Bioethics, praised the study
as a valiant attempt to build consensus,
but said it did not answer many questions
about the dangers involved in the
process.
''This
represents the right attitude, but I
think there are other methods that will
provide a wider range of cells and be
easier to accomplish,'' he said.
(AGENCIES)
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"Black
lung" still occurring in US miners
NEW YORK, Aug 25: Despite laws aimed
at limiting the amount of coal dust in
mines, coal miners are still coming down
with 'black lung' or pneumoconiosis,
according to a report from the Centers
for Disease Control and Prevention.
From March
to May of this year, the Coal Workers'
Health Surveillance Program identified 30
miners with pneumoconiosis out of a total
of 328 miners who were screened. Of
these, 11 had advanced disease, Dr V C
Antao and associates report in the CDC's
Morbidity and Mortality Weekly Report for
August 25.
The
Federal Coal Mine Health and Safety Act
of 1969 mandated limits of 2 milligrams
of dust per cubic meter in areas where
miners work. Subsequently, the rate of
occurrence of pneumoconiosis declined.
However, clusters of rapidly progressive
coal workers' pneumoconiosis began
reappearing in 1996, primarily in
Virginia and Kentucky.
Thirty-one
per cent of the estimated 1055
underground coal miners employed in
southwestern Virginia underwent screening
at mobile examination units, reports
Antao's team from the National Institute
for Occupational Safety and Health. The
subjects completed questionnaires
regarding their health and work history,
and underwent spirometry to determine
lung capacity, and chest X-rays.
As
mentioned, 30 (9 per cent) of those
screened had evidence of rapidly
progressive pneumoconiosis.
The 11
most advanced cases had worked in the
mines for an average of 31 years, and
only two subjects had started mining
before the 1969 limits took affect.
The
authors of a related editorial estimate
that 5.5 cases of advanced coal workers'
pneumoconiosis would be expected if dust
levels had not exceeded the current
limits. In contrast, 11.9 cases would be
expected if miners' exposure averaged
double the limit.
They
therefore suggest that mandated levels of
dust are too high, and should be lowered
to the ''recommended exposure limit'' of
1 milligram per cubic meter suggested by
the National Institute for Occupational
Safety and Health.
The
editorialists also note that the 11 cases
of advanced coal workers' pneumoconiosis
should be considered ''a sentinel health
event and justifies a comprehensive
assessment of current dust-control
levels.''(AGENCIES)
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Inflation
up at 4.92 pc
NEW DELHI, Aug 25: Wholesale
prices-based inflation rose to 4.92 per
cent during the week ended August 12,
compared to 4.82 per cent in the previous
week as essential items like fruits and
vegetables as well as some manufactured
products became dearer.
Inflation
was 3.67 per cent during the
corresponding week of the previous year.
If
inflation increases at the same rate next
week as well, it will cross the
psychological barrier of five per cent.
The
Government had to take steps to augment
supply of pulses, wheat and sugar after
inflation touched 5.24 per cent during
the week ended June 10 and then to 5.44
per cent the following week, which has
now been revised to 5.50 per cent.
Inflation
is slated to be between 5-5.5 per cent in
the current fiscal, as per the Reserve
Banks projection.
The Prime
Ministers advisory council has
predicted inflation to be around 5.5 per
cent at the end of this fiscal, compared
to 4.1 per cent last fiscal, in case
petroleum prices are further revised.
The index
for food articles, comprising essential
items, rose by 0.5 per cent to 204.8
points during the week ended August 12,
as fruits and vegetables became costlier
by two per cent each, and condiments and
spices by one per cent each.
However,
the prices of poultry chicken declined by
two per cent and masur by one per cent.
The index
for non-food articles category rose by
0.5 per cent to 184.7 points due to
higher prices of raw rubber by six per
cent, niger seed by five per cent and raw
cotton and groundnut seed by one per cent
each.
However,
the prices of raw silk fell by seven per
cent, raw jute by five per cent and
soyabean by one per cent.
The index
for fuel, power, light and lubricants
remained unchanged at 328.4 points.
The index
for manufactured products rose by 0.1 per
cent to 177.4 points.
Among food
products category of manufactured
products, imported edible oil became
dearer by five per cent, rice bran oil by
four per cent and gingelly oil and
groundnut oil by one per cent each.
However,
salt prices declined by 17 per cent, oil
cakes by two per cent and gur by one per
cent.
Among
textile items, polyester staple fibre
rose by three per cent, cotton yarn-cones
and hessian and sacking bags by one per
cent each.
However,
the prices of texturised yarn declined by
one per cent.
Duplex
board, among paper and paper products
group, rose by three per cent and cream
laid woven paper by one per cent.
Among
chemcials and chemical products group,
synthetic resins became dearer by nine
per cent, while liquid nitrogen fell by
two per cent and liquid chlorine and
caustic soda by one per cent each.
Building
bricks in the non-metallic mineral
products rose by two per cent.
In basic
metals alloys and metal products
group, ms/ss ingots went up by 23 per
cent, steel ingots by 15 per cent, zinc
by five per cent and lead ingots by three
per cent.
Bicycles
in the transport equipment and parts
category rose by seven per cent. (PTI)
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