150
stem cells lines needed for British therapeutic
bank
LONDON,
Dec 9:
Scientists have calculated that about 150 stem
cell lines derived from embryos would be needed
to one day establish a therapeutic stem cell bank
in Britain.
''The study,
although a simulation of the projected
requirements, provides the UK Stem Cell Bank with
initial targets for the population of a bank that
could meet long term therapeutic objectives,''
Justin St John said.
The lecturer at
the University of Birmingham in England said in a
commentary in The Lancet medical journal where
the findings were published on Friday that the
scale of what needs to be done is now clearer.
Stem cells have
the potential to provide new therapies for
diseases ranging from cancer and diabetes to
Alzheimer's disease and spinal cord injuries.
Britain set up the
world's first stem cell bank in May 2004 to store
and supply the cells for research and ultimately
treatments for human illnesses.
Although stem cell
therapies are still many years away, scientists
have tried to estimate the number of stem cell
lines -- reservoirs of cells derived from single
human embryo -- that would be needed to match
recipients in the most cases.
''We found that
about 150 donors would give a very good match for
about one in five recipients,'' Professor J.
Andrew Bradley, of Addenbrooke's Hospital in
Cambridge, England, told a news conference.
That number would
also provide a modest match for about 90 per cent
and an intermediate tissue match for about 50
percent to 70 per cent of patients.
The researchers
also identified a sub-set of stem cells from 10
human embryos that could theoretically provide a
very good match for about 38 per cent of
recipients.
MULTIPLE
RECIPIENTS
Like donor organs,
stem cells from a therapeutic bank need to be
matched to the recipient as closely as possible
to minimise the risk of rejection and the need
for immunosuppressant drugs.
But unlike a
heart, lung or liver transplant, which is
provided by one donor for one patient, a single
stem cell line could be used for multiple
recipients.
The use of
embryonic stem cells is controversial because the
master cells that can form into any cell type in
the body are derived from spare in-vitro
fertilisation (IVF) embryos.
Bradley and his
colleagues, who reported the findings in The
Lancet medical journal, estimated the number of
stem cell lines needed by analysing the blood
group and tissue types of 10,000 organs donors
for their compatibility to 6,577 patients
registered on the British kidney-transplant
waiting list.
''A bank of 150
donors provided the maximum utility,'' Bradley
explained, adding that full matches were found
for only 2 per cent of black and Asian
recipients.
Last week British
finance minister Gordon Brown announced the
country would double spending on stem cell
research to 100 million pounds (173 million
dollars) over the next 2 years. Part of the
funding will be used to support the stem cell
bank.
Britain, along
with South Korea, Singapore and the United
States, is one of the leaders in stem cell
research. Spain, the United States, Singapore
also have plans for stem cell banks. (AGENCIES)
Corruption
on increase worldwide, survey shows
LONDON,
Dec 9:
Corruption is on the increase in most countries
and poor people are often the hardest hit,
according to a global survey released today.
The poll,
published on United Nations Anti-Corruption Day,
found a majority of people in 48 out of 69
countries surveyed thought the problem had got
worse over the past three years.
''Today's survey
shows that people believe corruption is deeply
embedded in their countries,'' said Huguette
Labelle, chairwoman of anti-graft group
Transparency International, which commissioned
the Global Corruption Barometer research.
''When a poor
young mother believes that her Government places
its own interests above her child's, or that
securing services like that child's basic health
requires a hand under the table, her hope for the
future is dampened.''
Overall, people
rated political parties as the most corrupt
institutions. But customs officials were seen as
the most corrupt in many Central and Eastern
European states while the police and legal
systems often came top of the poll in Africa.
The survey also
showed paying bribes was not confined to specific
regions but was particularly prevalent in Central
and Eastern Europe, Africa and Latin America.
More than 30
percent of households in Cameroon, Paraguay,
Cambodia and Mexico had paid a bribe in the past
year.
Between 11 and 30
percent of households had done the same in a
further 22 countries, many of them developing
nations but also including European states such
as Greece and the Czech Republic.
People in Africa
-- the poorest continent -- appeared to pay the
highest proportion of their income in bribes, the
campaigning group said.
Top of that list
were Cameroon, Ghana and Nigeria, where
households paid more than 20 percent of national
per capital income in bribes.
Transparency
International, a Non-Governmental group based in
Berlin with branches in more than 90 countries,
said leaders could combat corruption if they made
a determined effort.
A UN convention
against Corruption, signed by 137 nations, enters
into force on December 14 and the group said
systems must be put in place to ensure
governments stick to their commitments.
''Signing the
document and taking part in the photo opportunity
is not enough,'' said chief executive David
Nussbaum.
Nearly 55,000
people in 69 countries were surveyed for the
Corruption Barometer as part of a Gallup poll
conducted between May and October 2005, the group
said. It said the survey would be posted on its
web site, www.Transparency.Org. (AGENCIES)
End
of the road for London's iconic Routemaster bus
LONDON,
Dec 9:
Britain's capital bids a fond farewell today to
the Routemaster double-decker bus that for half a
century has been as synonymous with London as Big
Ben.
Loved by tourists
and locals alike the distinctive red buses have
plied their trade since 1956, but deemed as
expensive antiques they have been gradually
retired since the 1980s.
At midday the last
Routemaster -- the number 159 -- will travel from
Oxford Street to Brixton bus garage in south
London, ringing in the end of an era.
Yesterday clusters
of amateur photographers could be seen along the
159's route eager to get a final snap of the
vehicle that is as famously British as Beefeaters
and red phone boxes.
The buses --
replete with a conductor, cord-pull bells and an
open rear boarding platform which allowed
passengers to get on and off even when the bus
was moving -- are viewed by many as irreplaceable
classics.
Few other buses
have fan clubs or a dedicated website.
''It's born of
London for London. And it's the last of its
kind,'' said Travis Elborough, author of ''The
Bus We Loved'' a homage to the buses, some of
which travelled continent-busting distances
during their long working lives.
''There is an
enormous sort of emotional attachment to these
buses,'' Elborough told Reuters.
''I think that a
lot of it is just that the experience of
travelling on them for many people is a lot more
pleasurable than maybe, travelling on certain
replacements which have all the aesthetics of the
inside of a hoover attachment.''
Snub-nosed and
light-bodied, with the driver enclosed in
splendid isolation in his cab, the last
Routemaster was built in 1968. They had been
designed to last no longer than 17 years.
Since the late
1950s countless visitors to London have climbed
the narrow stairs and settled into the front
seats for an inexpensive bird's eye tour of the
city's top attractions. At their peak 2,760
trundled throughout London.
And while
passengers will no longer be told to ''hold very
tight please'' as the conductor gave the
bell-cord two sharp tugs to signal the bus was
departing, not everyone will shed a tear.
The buses' design
effectively excluded many people with
disabilities and parents struggling with
pushchairs.
''While
Routemasters were operating, certain people
couldn't use them,'' Bert Massie, Chairman of the
Disability Rights Commission told Reuters.
He said he
understood the romance that surrounds the
Routemaster. But pointed out that a bus is a
means of getting from A to B and should fulfil
that role for all passengers.
''I have a certain
sympathy with the whole nostalgia thing, but the
world moves on,'' Massie said.
But the buses,
which starred in films and television series,
will not completely disappear -- a few will
continue on two London heritage routes for those
who can't let go. (AGENCIES)
Brain
cells by millions die during a stroke
NEW
YORK, Dec 9: When someone suffers a stroke, 1.9
million nerve cells in the brain die each minute,
and the oxygen-starved brain ages about 3.6 years
each hour -- further emphasizing the need for
rapid treatment -- researchers say.
''Time is brain'
is a popular saying: clinical outcomes have been
shown to deteriorate the longer treatment is
delayed,'' study author Dr Jeffrey L Saver, from
the University of California in Los Angeles, told
Reuters Health.
However, he added,
until recently the technology did not exist to
precisely count the number of neurons lost with
each passing minute that the blood supply is
interrupted to the affected region.
Advances in stroke
neuroimaging coupled with data from previous
research have allowed Saver to estimate the
neuron loss that occurs during a typical stroke.
The average stroke
involves 54 milliliters of brain tissue -- about
3 cubic inches -- and takes 10 hours to evolve,
the investigator reports in the American Heart
Association's journal Stroke.
As noted, each
minute a stroke ticks by untreated, 1.9 million
neurons die, resulting in the loss of 14 billion
synapses (nerve junctions) and 7.5 miles of nerve
fibers.
According to the
report, the forebrain, the most common site of
strokes, contains a total of 22 billion neurons,
on average.
''I was
simultaneously not surprised by the findings, but
astounded by the magnitude,'' Saver said. ''From
caring for patients whose lives are forever
altered by crippling stroke, I knew intuitively
that stroke is a devastating disease that evolves
rapidly. On the other hand, seeing the raw
numbers of exactly how much damage occurs
astounds me.''
The findings drive
home the message that ''patients need to
recognize stroke symptoms and call 911 right
away. ER physicians, neurologists, and nurses
need to recognize that stroke is a treatable
neuro emergency that has to be handled at the
highest triage priority.'' (AGENCIES)
US-India
relations at a "whole new level": Rocca
WASHINGTON,
Dec 9:
Terming the Indo-US ties as being on a "new
level", Assistant Secretary of State for
South Asia Christina Rocca has said the landmark
nuclear agreement between the two countries was
"well in train", brushing aside the
notion that Washington is "moving goal
posts" and bringing new conditions for
implementing it.
"We have
begun the conversation on the civilian nuclear
cooperation...There will be meetings coming up
this month and next month where we'll start
talking a little more concretely about how the
plan might look like, how we move forward,"
she said in an exclusive interview to PTI when
asked about the July 18 agreement which is yet to
be approved by the US Congress.
"We are very
busy with conversation on Capitol Hill, the Think
Tanks, with the Nuclear Suppliers Group,
international partners and friends...,"
Rocca said, while noting that there are "lot
of questions" in US Congress.
"I am
optimistic as to where we are going" she
said adding the civilian nuclear arrangement is
"well in train" and hoping that
legislation will come about in early 2006.
The agreement was
signed in Washington on July 18 between Prime
Minister Manmohan and President George W Bush,
under which the US implicitly recognised India as
a nuclear weapons state and agreed to supply fuel
for the Tarapore reactors following a series of
commitments by New Delhi, including that of
separating civilian and military facilities.
Rocca said the
July 18 meeting was in many ways the culmination
of "four years of hard work together to take
the relationship to a whole new level. So now we
have a new agenda that is on a totally different
level than we talk about it."
"A lot of
things are now givens. Our political
conversations are so drastically different from
four years ago. We are now on a new level,"
she said.
"It was a
pretty ambitious agenda that we set on July 18
and we've already started working on a number of
things."
She disagreed with
the argument that Washington and New Delhi had
moved "backwards" in that they first
came to a general agreement on the nuclear deal
and then sought to work on details and flush out
the political dynamics.
"I don't
agree with that perspective. What we agreed on is
a mutual goal that we will work towards. If you
look at the language it's very clear...It's a
very big change in US policy... This is a big
step forward. Had we done it the other way
around, it would not have worked. There is no
doubt about it," she said.
"...Working
out a deal like this means a lot of work on both
sides and there is no argument there," she
said, adding, "the dialogue (with US
Congress) has begun. The various elements that
needs to be done, certainly on our side are
moving along."
Rocca also brushed
aside the notion that the Bush administration has
resorted to moving the goal posts in the
aftermath of the accord on the civilian nuclear
deal or that it is asking New Delhi to do
something "more".
"No. That is
absolutely not. The language is carefully
drafted...I would absolutely say that no goal
posts were moved on both sides We are not asking
anything of India that we are not asking
ourselves, that we are not willing to do
ourselves.
"There is not
a question of moving goal posts. There are people
who are opposed to it who would like to frame it
that way. I think they are wrong," Rocca
countered.
She also disagreed
with a thinking that Bush should think of
postponing his India visit, now tentatively
scheduled for early next year, if the civilian
nuclear deal has not concretised. "I could
not disagree more," Rocca said.
"There are so
many things going on in the US-India relationship
on so many different frionts that are very good.
We are really happy he's going. This is a
relationship that has momentum, and the time to
go is exactly now. The relationship is not about
this one (nuclear) issue," she said.
Asked if the Bush
White House and the administration had the
"political capital" on Capitol Hill to
push this civilian nuclear agreement with India,
Rocca expressed optimism that members of Congress
"will see this in US interest, in India's
interest and also in the interests of the
non-proliferation regime as a whole."
Noting the
bilateral relationship has a lot of supporters,
she said, "US-India relations is a loss for
nobody. Everybody understands it."
"This
particular aspect (the civilian nuclear
agreement) has some controversy... We want to
make sure we're right. We believe it would be a
net gain for the world non-proliferation regime.
And it is a question of convincing that and
making our arguments; and I think we'll be able
to do it," she remarked.
Rocca stressed teh
Iran nuclear isse is very important for both the
administration and Congress. "We are very
grateful to the Indian vote at the IAEA... We
think we are on the same wavelength with India
and we hope we remain on this. It is important to
global security as a whole," she said.
The Assistant
Secretary of State for South Asia also praised
the statesmanship shown by leaders of India and
Pakistan and retierated the American position
that it is not the business of Washington to put
forth the way forward in the settlement of issues
between the two countries.
Rocca expressed
hope that the two countries will be able to keep
up the momentum in the peace process.
"We've said
all along that the solution to the problem is not
for the United States to forward...It certainly
wants to be as encouraging as it can. There is an
opportunity here, an opportunity and
statesmanship, that is shown on both sides that
is greatly appreciated by the U S administration.
"Our hope is
that both countries will be able to keep the
momentum that was created..," Rocca said.
She stressed that
the United States would like to see South Asian
region stable, democratic, peaceful with some
countries on the road to democracy, peace
processes successful and good governance.
"There are
enormous challenges as you can see," the
State Department official remarked pointing to
the goings on in Nepal and Sri Lanka.
On Nepal, Rocca
pointed out the steps that were taken
"backwards" from democracy "which
we believe fell right into the hands of the
Maoists--strengthening the hands of the
Maoists." (PTI)
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